ALK inhibitor 2
CAS No. : 761438-38-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $146 | In-stock |
| 5mg | $307 | In-stock |
| 10mg | $430 | In-stock |
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| Cat. No. : | HY-15358 |
| M.Wt: | 518.03 |
| Formula: | C23H28ClN7O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
ALK inhibitor 2 (compound 18) is a potent pyrimidin ALK inhibitor. ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM)[1]. IC50 & Target: IC50: 37 nM (TSSK2) and 5 nM (FAK)[1] In Vitro: Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. ALK inhibitor 2 (compound 18) contains a methylpiperazine A ring (R1=Me, X=N) and a D ring with R5=methylsulfonamide. ALK inhibitor 2 can undergo metabolic oxidation to form reactive adducts in the presence of glutathione[1].
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