SCH28080
CAS No. : 76081-98-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $100 | In-stock |
| 10mg | $170 | In-stock |
| 50mg | $620 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-103261 |
| M.Wt: | 277.32 |
| Formula: | C17H15N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity[1][2][3].
IC50 & Target: Ki: 0.12 μM ((H+/K+)-ATPase)[1]
In Vitro: SCH28080 competitively inhibits the K+-stimulated hydrolysis of ATP, with a Ki of 0.12 μM [1].
SCH28080 inhibits histamine-induced [14C]aminopyrine uptake into isolated rabbit parietal cells with an IC50 of 0.029 μM[1].
SCH28080 causes a dose-dependent reduction in cell viability with IC50 values of 22.9 µM and 15.3 µM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 µM already after 2 h treatment[2].
SCH28080 induces apoptosis and is cytotoxic at higher doses[2].
SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca2+ channels, reduces cell viability and dose-dependently induces apoptosis/necrosis[2].
In Vivo: SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats[3].
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