Tephrosin
CAS No. : 76-80-2
(Synonyms: Deguelinol I; Hydroxydeguelin)
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| Cat. No. : | HY-N1166 |
| M.Wt: | 410.42 |
| Formula: | C23H22O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1].
In Vitro: Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) [1].
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