Quassin
CAS No. : 76-78-8
(Synonyms: Nigakilactone D)
| Size | Price | Stock |
|---|---|---|
| 1mg | $90 | In-stock |
| 5mg | $360 | In-stock |
| 10mg | $480 | In-stock |
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| Cat. No. : | HY-N1581 |
| M.Wt: | 388.45 |
| Formula: | C22H28O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2]. IC50 & Target: IC50: 0.15 μM (P. falciparum)[2] In Vitro: Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3]. In Vivo: Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1].
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