Rhynchophylline
CAS No. : 76-66-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $94 | In-stock |
| 25mg | $155 | In-stock |
| 50mg | $232 | In-stock |
| 100mg | $350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0387 |
| M.Wt: | 384.47 |
| Formula: | C22H28N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research.[1][2][5][6].
In Vitro: Rhyncholphylline (0-30 μM, 48 h) inhibits the NO production, release of proinflammatory cytokines (TNF-α and IL-1β) in LPS-activated N9 microglial cells[1].
Rhyncholphylline (0-30 μM, 48 h) inhibits ERK and p38 MAPK phosphorylation in LPS-treated N9 microglial cells[1].
Rhyncholphylline inhibits ephrin-A1 induced tyrosine phosphorylation in rat cortical neurons[6].
In Vivo: Rhynchophylline (10 and 30 mg/kg, i.p., once daily for 4 days) protects rats from pMCAO surgery induced ischemic brain damage[2].
Rhynchophylline (100 µM, 2 µL, injected bilaterally in the hippocamp) shows neuroprotective effects against Aβ1-42-induced neurotoxicity in rats[5].
Rhynchophylline (50 mg/kg, p.o., daily, 3-4 weeks) inhibits EphA4 activation in the hippocampus of APP/PS1 mice[6].
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