Melanotan I
CAS No. : 75921-69-6
(Synonyms: MT-I; [Nle4,D-Phe7]-α-MSH)
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $105 | In-stock |
| 10mg | $160 | In-stock |
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| Cat. No. : | HY-N2466 |
| M.Wt: | 1646.85 |
| Formula: | C78H111N21O19 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL |
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction[1][2][3][4].
In Vitro: Melanotan I (1 μM, 72 h) does not alter or slightly inhibit the formation of tumor colonies, and inhibits melanoma cell proliferation in vitro[3].
In Vivo: Melanotan I (2 mg/kg/dayfor 12 weeks, s.c.) has no acute toxic effect in rodents[2].
Melanotan I (2/10 mg/kg, s.c.) does not increase tumor incidence of human melanoma in SCID (immunodeficient) mice, nor does it lead to malignant transformation of tumors, and does not exhibit cancer-promoting effects. [3].
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