AZD4877
CAS No. : 758722-49-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $168 | In-stock |
| 5mg | $385 | In-stock |
| 10mg | $575 | In-stock |
| 25mg | $1035 | In-stock |
| 50mg | $1553 | In-stock |
| 100mg | $2330 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13224 |
| M.Wt: | 503.66 |
| Formula: | C28H33N5O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity[1][2][3][4][5].
IC50 & Target:IC50: 2 nM (Eg5)[5]
In Vitro: AZD4877 (10 nM, 24 or 48 hours) induces apoptosis in human bladder cancer cells and AZD4877-sensitive cells generally expressed high levels of p63[2].
In Vivo: AZD4877 (i.v., 6 mg/kg, 12 mg/kg; single dose) has a significant reduction in cell viability and increase in cleaved caspase 3 levels by 48 h post dose in a rat hollow fiber model[1].
AZD4877 (i.v., 6 mg/kg; single dose) shows a T1/2 of 3.5 h, and CL of 36 mL/min/kg in Hans Wistar rats[1].
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- Cat. No.:
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