Rimcazole (dihydrochloride)
CAS No. : 75859-03-9
(Synonyms: BW 234U (dihydrochloride))
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|---|---|---|
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| 100mg | $990 | In-stock |
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| Cat. No. : | HY-108510 |
| M.Wt: | 394.38 |
| Formula: | C21H29Cl2N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can attenuate cocaine-induced locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer[1][2][3][4].
IC50 & Target: sigma (σ) receptor[1]
dopamine transporter[1]
In Vitro: Rimcazole (1-50 μM; 24-48 h) concentration-dependently decreases the number HCT-116p53+/+ cells[2].
Rimcazole (50 μM; 1-24 h) dihydrochloride induces a transient accumulation of HIF-1α protei in cancer cells (HCT-116p53+/+ and MDA MB 231 cells) but not in normal human dermal fibroblasts[2].
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