Tanespimycin (Standard)
CAS No. : 75747-14-7
(Synonyms: 17-AAG (Standard); NSC 330507 (Standard); CP 127374 (Standard))
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| Cat. No. : | HY-10211R |
| M.Wt: | 585.69 |
| Formula: | C31H43N3O8 |
| Purity: | >98 % |
| Solubility: |
Tanespimycin (Standard) is the analytical standard of Tanespimycin. This product is intended for research and analytical applications. Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90[1][5]. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression[3]. IC50 & Target:IC50: 5 nM (HSP90)[5]
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