Methyl 1-Cbz-azetidine-3-carboxylate
CAS No. : 757239-60-4
| Size | Price | Stock |
|---|---|---|
| 10g | $25 | In-stock |
| 25g | $58 | In-stock |
| 50g | $110 | In-stock |
| 100g | $220 | In-stock |
| 500g | $1100 | In-stock |
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| Cat. No. : | HY-W019226 |
| M.Wt: | 249.27 |
| Formula: | C13H15NO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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