Imanixil
CAS No. : 75689-93-9
(Synonyms: HOE-402(free base))
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $550 | In-stock |
| 10mg | $950 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-101529 |
| M.Wt: | 394.35 |
| Formula: | C17H17F3N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Imanixil (HOE-402 free base) is an orally active LDL receptor (LDLR) inducer. Imanixil can reduce cholesterol levels by inhibiting VLDL-lipid production. Imanixil can delay atherosclerosis profession. Imanixil can be used for the research of cardiovascular disease, such as atherosclerosis[1].
In Vitro:Imanixil shows no inhibitory effect on ACAT activity and does not upregulate hepatic HMG-CoA synthase mRNA levels in HepG2 cells[1].
Imanixil increases LDL-binding sites and LDLR mRNA levels in HepG2 cells[1].
In Vivo:Imanixil (50 mg/kg, p.o., 4-21 weeks) reduces cholesterol levels and delays atherosclerosis in wild-type and LDL receptor-deficient mice[1].
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