NH2-PEG8-acid
CAS No. : 756526-04-2
| Size | Price | Stock |
|---|---|---|
| 250mg | $67 | In-stock |
| 1g | $173 | In-stock |
| 5g | $591 | In-stock |
| 25g | $2069 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-W019798 |
| M.Wt: | 441.51 |
| Formula: | C19H39NO10 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. In Vitro:ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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