Pentamethoxymorin
CAS No. : 7555-80-8
(Synonyms: MRS923)
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| Cat. No. : | HY-118083 |
| M.Wt: | 372.37 |
| Formula: | C20H20O7 |
| Purity: | >98 % |
| Solubility: |
Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer[1]. In Vitro:Pentamethoxymorin (compound 11) (0.031-100 µM; 30 min-72 h) inhibits BCRP and weakly inhibits P-gp, with no MRP1 inhibition and low cytotoxicity (IC50 = 5.94-5.98 μM for BCRP, 27.1 μM for P-gp)[1].
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