EHT 1864
CAS No. : 754240-09-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $105 | In-stock |
| 10mg | $172 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $435 | In-stock |
| 100mg | $657 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16659 |
| M.Wt: | 581.48 |
| Formula: | C25H29Cl2F3N2O4S |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : ≥ 32 mg/mL |
EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.?EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ?40 and Aβ?42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG[1][2][3][4]. In Vivo:EHT 1864 (oral administration) displays good tolerability, brain penetrance, and no genotoxicity.?EHT 1864 (10 and 40 mg/kg/day; daily; 15 days; intraperitoneal injections) lowers brain Aβ 40 by 37% in guinea pigs[1].
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