Paromomycin
CAS No. : 7542-37-2
(Synonyms: Aminosidine)
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| Cat. No. : | HY-B0956A |
| M.Wt: | 615.63 |
| Formula: | C23H45N5O14 |
| Purity: | >98 % |
| Solubility: |
Paromomycin (Aminosidine) is an orally active broad-spectrum aminoglycoside aminocyclitol. Paromomycin is produced by Streptomyces riomosus var. Paromomycinus. Paromomycin binding induces local conformational changes in the 16S rRNA A-site. Paromomycin exhibits inhibitory activity against C. parvum. Paromomycin can be used in research related to leishmaniasis, amoebiasis and cryptosporidiosis[1][2][3]. In Vitro:Paromomycin inhibits Cryptosporidium parvum infection of the differentiated human enterocyte cell line HT29.74[3]. In Vivo:Paromomycin (1-2 g/kg/day; p.o.; 10 consecutive days) reduces C. parvum infection in immunosuppressed adult C57BL/6N mice, as demonstrated by significant reductions in fecal oocyst shedding (P < 0.01), parasite colonization (P < 0.05), and villus atrophy (P < 0.05) in the ilea and terminal ilea[3].
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