NS-6740


CAS No. : 753500-02-6

753500-02-6
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Cat. No. : HY-118646
M.Wt: 364.36
Formula: C19H19F3N2O2
Purity: >98 %
Solubility:
Introduction of 753500-02-6 :

NS-6740 is a partial agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC50 of 3 nM. NS-6740 also acts as a potent modulator of the cholinergic anti-inflammatory pathway. NS-6740 alters the signaling pattern of α7 in an ion channel-independent manner, thereby reducing synaptic function. NS-6740 induces the desensitized state of α7 nAChR. NS-6740 generates robust nAChR-mediated currents. NS-6740 reduces LPS (HY-D1056)-induced TNF-α release from microglia. NS-6740 can be used in the research of neuroinflammation and neuropathic pain[1][2].

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