NS-6740
CAS No. : 753500-02-6
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| Cat. No. : | HY-118646 |
| M.Wt: | 364.36 |
| Formula: | C19H19F3N2O2 |
| Purity: | >98 % |
| Solubility: |
NS-6740 is a 7 nAChRs partial agonist with a Ki of 1.1 nM. NS-6740 is also an effective modulator of the cholinergic anti-inflammatory pathway. NS-6740 switched the signaling mode of 7 in a channel-independent manner, which reduces synaptic function. NS-6740 can induce the desensitization state of 7 nAChRs. NS-6740 can result in the generation of robust nAChR-mediated currents. NS-6740 reduces lipopolysaccharide-induced TNF-α release from microglia. NS-6740 can be studied in research on inflammatory and neurological disease such as chronic and neuropathic pain[1][2][3].
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