MK-0941 (free base)
CAS No. : 752240-01-0
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| Cat. No. : | HY-19843A |
| M.Wt: | 460.50 |
| Formula: | C21H24N4O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes[1][2]. IC50 & Target:Glucokinase[1][2]. In Vivo:MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse[1].
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