EBOV-IN-11
CAS No. : 752216-12-9
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| Cat. No. : | HY-125258 |
| M.Wt: | 475.50 |
| Formula: | C26H25N3O6 |
| Purity: | >98 % |
| Solubility: |
EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with Kd values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection[1].
In Vitro:EBOV-IN-11 (Compound C31) (10 μM; 3 d) inhibits the replication of EBOV-eGFP in Vero E6 cells with low initial cytotoxicity[1].
EBOV-IN-11 (100 μM) exhibits <30% cytotoxicity in 293T cells, while it shows no cytotoxicity in PBMCs[1].
EBOV-IN-11 (1-30 μM; 49 h) potently inhibits EBOV replication in Vero E6 cells at concentrations of 3 μM and above, reducing viral titers by 2-3 orders of magnitude[1].
EBOV-IN-11 (10 μM; 48 h) inhibits the transcription of EBOV minigenome in 293T cells, with inhibitory potency comparable to that of 1E7-03[1].
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Inquiry Information- Product Name:
- EBOV-IN-11
- Cat. No.:
- HY-125258
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