Araloside A
CAS No. : 7518-22-1
(Synonyms: Chikusetsusaponin IV)
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $90 | In-stock |
| 10mg | $130 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N2115 |
| M.Wt: | 927.08 |
| Formula: | C47H74O18 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis[1][2][3][4].
IC50 & Target:IC50: 77.4 μM (Renin)[1]
In Vitro:Araloside A (1-100 μM, 24-72 h) reduces cellular viability and induces apoptosis in GRC-1 and 786-O cells[2].
Araloside A (1-32 μM, 24 h) inhibits proliferation in MH7A cells[3].
Araloside A (4-16 μM, 24 h) induces apoptosis in MH7A cells[3].
Araloside A (4-16 μM, 24 h) suppresses IL-1β, IL-6, NO and PGE2 levels and inhibits NF-κB pathway in MH7A cells[3].
In Vivo:Araloside A (10-40 mg/kg, i.g., daily for 7 days) shows protective effect in gastric ulcer mice models[1].
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