Araloside A (Standard)
CAS No. : 7518-22-1
(Synonyms: Chikusetsusaponin IV (Standard))
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| Cat. No. : | HY-N2115R |
| M.Wt: | 927.08 |
| Formula: | C47H74O18 |
| Purity: | >98 % |
| Solubility: |
Araloside A (Standard) (Chikusetsusaponin IV (Standard)), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A (Standard) shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A (Standard) can inhibit cell proliferation and induce apoptosis. Araloside A (Standard) suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A (Standard) can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis[1][2][3][4].
IC50 & Target:IC50: 77.4 μM (Renin)[1]
In Vitro:Araloside A (Standard) (1-100 μM, 24-72 h) reduces cellular viability and induces apoptosis in GRC-1 and 786-O cells[2].
Araloside A (Standard) (1-32 μM, 24 h) inhibits proliferation in MH7A cells[3].
Araloside A (Standard) (4-16 μM, 24 h) induces apoptosis in MH7A cells[3].
Araloside A (Standard) (4-16 μM, 24 h) suppresses IL-1β, IL-6, NO and PGE2 levels and inhibits NF-κB pathway in MH7A cells[3].
In Vivo:Araloside A (Standard) (10-40 mg/kg, i.g., daily for 7 days) shows protective effect in gastric ulcer mice models[1].
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