PRE-084 (hydrochloride)
CAS No. : 75136-54-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $48 | In-stock |
| 10mg | $75 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $550 | In-stock |
| 200mg | $990 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-18100A |
| M.Wt: | 353.88 |
| Formula: | C19H28ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL;H2O : 33.33 mg/mL (ultrasonic;warming;heat to 60°C) |
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].
In Vitro: PRE-084 hydrochloride (0.1-100 µM; 24 h) protects cultured cortical neurons against β-amyloid toxicity (maximally neuroprotective at 10 µM) and reduces the levels of proapoptotic protein Bax at 10 µM[1].
In Vivo: PRE-084 hydrochloride (0.25 mg/kg; i.p.; 3 times a week for 8 weeks) displays beneficial effects on motor performance (improves motor neuron survival, ameliorates paw abnormality and grip strength performance) in wobbler mice, and shows neuroprotective effects (increases the levels of BDNF in the gray matter)[2].
PRE-084 hydrochloride (1 mg/kg; i.p.; single) protects the heart by activating the Akt‑eNOS pathway in myocardial infarction model[3].
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