RU28362
CAS No. : 74915-64-3
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| Cat. No. : | HY-121859 |
| M.Wt: | 352.47 |
| Formula: | C23H28O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro:RU28362 (0.1, 1, 5, 10 nM; 72 h) increases the Bnip3 mRNA levels in a dose-dependent manner after 72 h in neurons[1]. In Vivo:RU28362 (150 μg/kg; i.p.) inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland[2].
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