YC-001
CAS No. : 748778-73-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124717 |
| M.Wt: | 282.77 |
| Formula: | C12H7ClO2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration[1].
In Vitro: YC-001 (0-100 μM) shows a potency activity of 8.7 μM and an efficacy at 150-310%[1].
YC-001 (0.5, 1, 5, 10, 20, 40 μM) improves the glycosylation profile of P23H opsin mutant[1].
YC-001 (0,-1.5 μM) reversibly binds rod opsin with EC50 OF 0.98 μM[1].
YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 μM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells[1].
In Vivo: YC-001 (50, 200mg/kg; i.p.) protects Abca4?/?Rdh8?/? mice from bright light-induced retinal degeneration[1].
YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods[1].
YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity[1].
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