Zalcitabine
CAS No. : 7481-89-2
(Synonyms: 2',3'-Dideoxycytidine; ddC; Dideoxycytidine)
| Size | Price | Stock |
|---|---|---|
| 100mg | $32 | In-stock |
| 250mg | $49 | In-stock |
| 1g | $138 | In-stock |
| 5g | $435 | In-stock |
| 25g | $1485 | In-stock |
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| Cat. No. : | HY-17392 |
| M.Wt: | 211.22 |
| Formula: | C9H13N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic);H2O : ≥ 25 mg/mL |
Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. IC50 & Target:Target: HIV In Vitro: Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[1]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[2].
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