PBT 1033
CAS No. : 747408-78-2
(Synonyms: PBT 2)
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
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| Cat. No. : | HY-105321 |
| M.Wt: | 271.15 |
| Formula: | C12H12Cl2N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
In Vitro:PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5 μM[2].
PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity[3].
PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons[3].
PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells[4].
PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates[5].
In Vivo:PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease[5].
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