Zaltoprofen
CAS No. : 74711-43-6
(Synonyms: CN100)
| Size | Price | Stock |
|---|---|---|
| 5mg | $46 | In-stock |
| 10mg | $72 | In-stock |
| 50mg | $149 | In-stock |
| 100mg | $204 | In-stock |
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| Cat. No. : | HY-B0619 |
| M.Wt: | 298.36 |
| Formula: | C17H14O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].
In Vitro: Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner[1].
Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells[1].
Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells[2].
In Vivo: Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats[2].
Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner[2].
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