D-64131
CAS No. : 74588-78-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $135 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15482 |
| M.Wt: | 251.28 |
| Formula: | C16H13NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1][2].
IC50 & Target: IC50: 0.53 μM (tubulin polymerization)[2]
In Vitro: D-64131 is antimitotic by binding to β-tubulin, thereby destabilizing microtubules and arresting mitotic cells in the M-phase[1].
D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM[1].
D-64131 is cytotoxic toward MDR/MRP tumor cell lines[1].
D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM, respectively[2].
In Vivo: D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model[1].
D-64131 has oral bioavailability and is well tolerated at efficacious doses[1].
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