Vecuronium (maleate)
CAS No. : 74531-76-3
(Synonyms: ORG NC 45 (maleate))
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| Cat. No. : | HY-B0118B |
| M.Wt: | 753.80 |
| Formula: | C38H61BrN2O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Vecuronium (ORG NC 45) maleate is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor. Vecuronium (ORG NC 45) maleate is a muscle relaxant and can be used for pre-surgical anesthesia[1][2]. In Vitro: Vecuronium maleate (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells[1]. Vecuronium maleate (0-15 μM,72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner[2]. Vecuronium maleate (0-15 μM,72 hours) can significantly reduce cell viability by combining with cisplatin[2]. In Vivo: Vecuronium maleate (intravenous injection, 0-5 μM, every 30 min, 2 hours) attenuates the response of carotid sinus nerve activity (CSNA) to hypoxia in a dose-dependent manner and inhibits the neural response of the carotid body to acetylcholine (ACh) in Wister rats[3].
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