Prostaglandin E1

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases^[1][2][3]. IC50 & Target: Ki: 1.1 nM (mouse EP3), 2.1 nM (mouse EP4), 10 nM (mouse EP2), 33 nM (mouse IP), 36 nM (mouse EP1) Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases^[1][2][3]. In Vitro: Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC₅₀ of 400 nM^[2].
Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC₅₀ of 500 nM^[2].
Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis^[2].
Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs^[2]. In Vivo: Prostaglandin E1 (20 ng/animal/day; s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice^[2].