Imipenem (monohydrate)
CAS No. : 74431-23-5
(Synonyms: N-Formimidoyl thienamycin (monohydrate); MK0787 (monohydrate))
| Size | Price | Stock |
|---|---|---|
| 100mg | $46 | In-stock |
| 250mg | $58 | In-stock |
| 1g | $70 | In-stock |
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| Cat. No. : | HY-B1369 |
| M.Wt: | 317.36 |
| Formula: | C12H19N3O5S |
| Purity: | >98 % |
| Solubility: | H2O : 6.25 mg/mL (ultrasonic;warming;heat to 60°C) |
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].
In Vivo: Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].
| Drug and dose(mg/kg) | Cmax(mg/liter) | Tmax(min) | AUCtot(mg ? min/liter) | Vz/F(ml/kg) | Vss/F (ml/kg) | CL/F(ml/min/kg) | t1/2(min) | MRT(min) |
| Imipenem | ||||||||
| 8 | 15 (7.1) | 21 (11) | 1,470 (777) | 648 (330) | 721 (343) | 6.7 (3) | 67 (11) | 108 (12) |
| 16 | 34 (6) | 28 (18) | 2,857 (559) | 507 (140) | 543 (121) | 5.8 (1) | 60 (9.1) | 94 (10) |
| 32 | 54 (11) | 18 (6.1) | 4,895 (635) | 516 (75) | 566 (83) | 6.6 (0.8) | 54 (6.5) | 86 (11) |
| 64 | 69 (37) | 15 (9.5) | 6,037 (2,976) | 547 (274) | 617 (308) | 7.4 (3.6) | 43 (22) | 70 (35) |
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