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Fenclonine


CAS No. : 7424-00-2

(Synonyms: 4-Chloro-DL-phenylalanine; PCPA; CP-10188)

7424-00-2
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Cat. No. : HY-B1368
M.Wt: 199.64
Formula: C9H10ClNO2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic;adjust pH to 2 with HCl);H2O : 4 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 7424-00-2 :

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1][2][3]. In Vivo:Fenclonine (intraperitoneal injection; 100 mg/kg; once daily; 3 d) treatment can inhibit Morphine-induced anti-nociceptive activity[2].
Fenclonine (intraperitoneal injection; 300 mg/kg; once daily; 3 d) pretreatment completely abolishes the effects of a 50 mg/kg dose of Paracetamol[3].
Fenclonine can be used for animal modeling and constructing insomnia models[4]

1. Induction of insomnia[4]
Background
Fenclonine can inhibit the synthesis of serotonin (5-HT), induce 5-HT depletion, and lead to insomnia.
Specific Mmodeling Methods
Rat: Sprague-Dawley (SD) • male • 6-8 weeks old
Administration: 300 mg/kg • i.p. • once daily for 3 days
Note
(1) Preparatory training for the forced swim test (FST) and the tail-suspension test (TST) was performed on day 3 post-treatment, and immobility times for the FST and TST were measured on day 6.
(2) After 7 days of treatment, the rats were executed, the brains were removed and immediately placed on ice while the hippocampus was isolated and the protein concentration of the brain was analysed by Western blotting.
(3) Isolated rat brains were fixed in 4% paraformaldehyde for 2-3 hours, and rat brain sections were cut at a thickness of 16 μm on a cryosectioner for immunofluorescence.
Modeling Indicators
Molecular changes: Downregulation of 5-HT1AR expression.
Phenotypic observation: Increased immobility time and weight loss in the forced swim test (FST) and the tail suspension test (TST).
Correlated Product(s):
Buspirone (HY-B1115A)

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