Fenclonine


CAS No. : 7424-00-2

(Synonyms: 4-Chloro-DL-phenylalanine; PCPA; CP-10188)

7424-00-2
Price and Availability of CAS No. : 7424-00-2
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Cat. No. : HY-B1368
M.Wt: 199.64
Formula: C9H10ClNO2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic;adjust pH to 2 with HCl);H2O : 4 mg/mL (ultrasonic;warming;heat to 60°C);1 M NaOH : 150 mg/mL (ultrasonic)
Introduction of 7424-00-2 :

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1][2][3]. In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Fenclonine can be used in animal modeling to create insomnia models[4].

1. Induction of insomnia[4]
Background
Fenclonine can inhibit the synthesis of serotonin (5-HT), induce 5-HT depletion, and lead to insomnia.
Specific Modeling Methods
Rat: Sprague-Dawley (SD) • male • 6-8 weeks old
Administration: 300 mg/kg • i.p. • once daily for 3 days
Note
Start injecting Fenclonine three days after administration.
Modeling Indicators
Molecular changes: Downregulation of 5-HT1AR expression.
Opposite Product(s): Buspirone (HY-B1115A)

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