Dazoxiben (hydrochloride)


CAS No. : 74226-22-5

(Synonyms: UK 37248)

74226-22-5
Price and Availability of CAS No. : 74226-22-5
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Cat. No. : HY-106067A
M.Wt: 268.70
Formula: C12H13ClN2O3
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL
Introduction of 74226-22-5 :

Dazoxiben hydrochloride is a potent and orally active thromboxane (TX) synthase inhibitor[1]. IC50 & Target:Thromboxane (TX) synthase[1] In Vitro: Dazoxiben hydrochloride inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production[1].
Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production[1].
In Vivo: Dazoxiben hydrochloride (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs[2].

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