Etidronic acid (disodium)
CAS No. : 7414-83-7
(Synonyms: Etidronate (disodium); HEDPA (disodium); HEDP (disodium))
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| 100g | $131 | In-stock |
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| Cat. No. : | HY-B0302A |
| M.Wt: | 249.99 |
| Formula: | C2H6Na2O7P2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water[1][2][3][4].
In Vitro:Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells[3].
Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy[5].
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