SKF 83822
CAS No. : 74115-08-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $750 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1900 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-116874 |
| M.Wt: | 343.85 |
| Formula: | C20H22ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia[1][2].
In Vivo:SKF 83822 (25-100 μg/kg; s.c.; single dose after antagonist) produces a strong rotational response in rat in a dose-dependent manner. And it also stimulates strong expression of the IEG products c-Fos, Fra2, Zif/268 and Arc in the deinnervated striatum[1].
SKF 83822 shows significant effects in a moderate and high dose with 0.25 mg/kg and 0.35 mg/kg, respectively, in monkeys. And it (0.15-0.35 mg/kg; s.c.; single dose) induces locomotion but nor inducing dyskinesia. SKF 83822 results in a state of extreme arousal and locomotor activation without stereotypy[2].
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