(E/Z)-BIO-acetoxime
CAS No. : 740841-15-0
(Synonyms: GSK-3 Inhibitor X)
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| Cat. No. : | HY-114903 |
| M.Wt: | 398.21 |
| Formula: | C18H12BrN3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1]. In Vitro: E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC50s of 0.01, 2.4, 4.3 and 63 μM, respectively[1].
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