p-Hydroxycinnamic acid
CAS No. : 7400-08-0
| Size | Price | Stock |
|---|---|---|
| 10g | $11 | In-stock |
| 25g | $18 | In-stock |
| 100g | $68 | In-stock |
| 500g | $82 | In-stock |
| 1000g | $161 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-N2391 |
| M.Wt: | 164.16 |
| Formula: | C9H8O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;Ethanol : 33.33 mg/mL (ultrasonic) |
p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. IC50 & Target: IC50: 371 μM (thromboxane B2), 126 μM (prostaglandin E2)[1]. In Vitro: p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55?2 (SE 4?01) % and 35?6 (SE 2?35) % relative to basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].
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