Mosloflavone


CAS No. : 740-33-0

740-33-0
Price and Availability of CAS No. : 740-33-0
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Cat. No. : HY-N2036
M.Wt: 298.29
Formula: C17H14O5
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 740-33-0 :

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation. IC50 & Target: IC50: EV71; bacterial[1][2] In Vitro: Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2].

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