Anagliptin
CAS No. : 739366-20-2
(Synonyms: SK-0403)
| Size | Price | Stock |
|---|---|---|
| 5mg | $115 | In-stock |
| 10mg | $170 | In-stock |
| 50mg | $425 | In-stock |
| 100mg | $640 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14877 |
| M.Wt: | 383.45 |
| Formula: | C19H25N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively[1].
IC50 & Target:IC50: 3.8 nM (DPP-4), 68 nM (DPP-8), 60 nM (DPP-9)[1]
In Vitro: Anagliptin (SK-0403) (0-100 μM; 24 h) attenuates s-DPP-4-induced smooth muscle cells proliferation[2].
Anagliptin (100 μM; 10 min) reduces TNF-α production in cultured monocytes[2].
Anagliptin (0.001-10 μM; 24 h) significantly suppresses sterol regulatory element-binding protein activity in HepG2 cells (21% decrease)[3].
In Vivo: Anagliptin (SK-0403) (0.3%; in diet; 16 weeks) reduces atherosclerotic lesion and does not increase the number of circulating EPCs in apoliporotein E (apoE)-deficient mice[2].
Anagliptin (0.3%; in diet; 4 weeks) exhibits a lipid-lowering effect in a hyperlipidemic mice model[3].
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