1-Deoxymannojirimycin (hydrochloride)

1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. 1-Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . 1-Deoxymannojirimycin hydrochloride increases high mannose structures. 1-Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer^{[1][2][3][4][5][6]}. IC50 & Target:IC50: 20 μM (α1,2-mannosidase I)^[1]
N-linked glycosylation^[2]
HIV‐1^[2] In Vitro:1-Deoxymannojirimycin (2 mM; 24 h) hydrochloride inhibits Golgi α-mannosidase I and leads to an increase in high mannose structures in P815 and EL-4 cells^[1].
1-Deoxymannojirimycin (4-5 days) hydrochloride shows antiviral efficacy against mutant HIV-1 strains in CEM cell cultures, with EC₅₀ values ranging between 90 and 155 μM^[2].
1-Deoxymannojirimycin (100-250 μM) hydrochloride potentiates the antiviral efficacy of CBAs (HHA and GNA) against wild-type HIV-1 replication in CEM cell cultures^[2].
1-Deoxymannojirimycin (1 mM; 8 h) hydrochloride induces the activation and up-regulation of key molecules of ER stress-UPR, such as GRP78/Bip and XBP1, in human hepatocarcinoma 7721 cells^[3].
1-Deoxymannojirimycin (150 μM; 15 h) hydrochloride causes the accumulation of Man8GlcNAc2 on 97-kDa HMG-CoA reductase in UT-1 cells^[4].
1-Deoxymannojirimycin (2 mM) hydrochloride completely inhibits α-mannosidase I activity in both differentiated and undifferentiated HT-29 cells^[5].