Sulmazole
CAS No. : 73384-60-8
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| Cat. No. : | HY-116675 |
| M.Wt: | 287.34 |
| Formula: | C14H13N3O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Sulmazole is a cardiotonic agent. Sulmazole has competitive inhibitory for A1 adenosine receptor. Sulmazole can improve cardiac index and reduce pulmonary capillary wedge pressure[1].
In Vitro:Sulmazole has competitive inhibitory for A1 adenosine receptors[1].
Sulmazole attenuates the capacity of GTP to inhibit adenylate cyclase activity and covalent modification of Gi by pertussis toxin treatment abolishes the capacity of sulmazole to mediate stimulation[1].
Sulmazole has stimulatory effect on adenylate cyclase activity in pertussis toxin-treated membranes[1].
Sulmazole mediates increases in cAMP accumulation by mechanisms other than phosphodiesterase inhibition, including A1 adenosine receptor antagonism and inhibition of Gi function[1].
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