Niclosamide (monohydrate)
CAS No. : 73360-56-2
(Synonyms: BAY2353 monohydrate)
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| Cat. No. : | HY-B0497B |
| M.Wt: | 345.13 |
| Formula: | C13H10Cl2N2O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].
IC50 & Target: IC50: 0.25 μM (STAT3)[1]
In Vitro: Niclosamide monohydrate (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].
Niclosamide monohydrate (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells [4].
Niclosamide monohydrate (10 μM) treatment inhibits virus replication in Vero E6 cells[5].
In Vivo: Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].
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