Trifluridine/tipiracil hydrochloride mixture
CAS No. : 733030-01-8
(Synonyms: TAS-102; FTD/TPI)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $319 | In-stock |
| 100mg | $495 | In-stock |
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| Cat. No. : | HY-16478 |
| M.Wt: | 435.76 |
| Formula: | C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl |
| Purity: | >98 % |
| Solubility: | DMSO : 2.34 mg/mL (ultrasonic;warming);H2O : 100 mg/mL (ultrasonic);DMF : 20 mg/mL (ultrasonic) |
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2]. In Vivo: Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2].
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