Florfenicol

Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions^[6][7].
In Vitro:Florfenicol (0.025, 0.1, 0.4 mg/mL, 48 h) inhibits fibroblast proliferation and autophagy by inducing mitochondrial dysfunction^[1].
Florfenicol (0.097-200 μg/mL, 24 h) exhibited cytotoxic effects on Unio crusus and Cyprinus carpio primary cell lines and reduced primary cell viability^[2].
In Vivo:Florfenicol (10-90 mg/kg, p.o.) exhibits toxicity to developing chicks and can induce early embryonic death^[3].
Florfenicol (0.15 g/L, 5 days, p.o.) induces renal inflammatory response and cell apoptosis in chicks by activating the cell adhesion molecule signaling pathway^[4].
Florfenicol (30 mg/kg, 8 days, p.o.) exhibits regulatory effects on lymphocyte subsets and humoral immune responses in sheep red blood cell immunized broiler chickens^[5].
Florfenicol (5, 25, 100 mg/kg, 4 days, p.o.) inhibits allergic airway inflammation in mice through p38 MAPK mediated GATA 3 phosphorylation ^[6].
Florfenicol (50, 100, 200 mg/kg, 10 days, p.o.) can inhibit humoral and cellular immune responses in mice^[7].