Eicosapentaenoic Acid (sodium)
CAS No. : 73167-03-0
(Synonyms: EPA (sodium); Timnodonic acid (sodium))
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| Cat. No. : | HY-W011269 |
| M.Wt: | 324.43 |
| Formula: | C20H29NaO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
In Vitro: C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1].
Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1].
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