Hydroxyrubicin
CAS No. : 73113-90-3
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| Cat. No. : | HY-105510 |
| M.Wt: | 544.50 |
| Formula: | C27H28O12 |
| Purity: | >98 % |
| Solubility: |
Hydroxyrubicin is an antitumor agent. Hydroxyrubicin can induce topoisomerase II-mediated DNA cleavage. Hydroxyrubicin induces DNA unwinding. Hydroxyrubicin has a significant inhibitory effect on tumor cells. Hydroxyrubicin can be used for the study of Multidrug-resistant (MDR) leukemia[1][2].
In Vitro:Hydroxyrubicin (1-10 μM, 30 min) induces topoisomerase II-mediated DNA cleavage in human c-myc-origin DNA[1].
Hydroxyrubicin (2.5-10 μM, 30 min) induces concentration-dependent DNA unwinding[1].
Hydroxyrubicin (1 h) appears to be slightly more cytotoxic than Doxorubicin (HY-15142A) in the sensitive KB3.1 cell line (IC50: 0.35 μM and 0.8 μM) and is 20-fold more cytotoxic on KB-V1 cells than doxorubicin (IC50: 2 μM and 40 μM)[1].
In Vivo:Hydroxyrubicin (25-79.1 mg/kg, i.v., once/once weekly for 11 weeks) significantly reduces acute toxicity and cardiotoxicity in mice by removing the C-3' amino group of Doxorubicin (HY-15142A), while maintaining antitumor activity in the P388/Dox cell xenograft mouse model[2].
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