Guanine
CAS No. : 73-40-5
| Size | Price | Stock |
|---|---|---|
| 25g | $11 | In-stock |
| 100g | $19 | In-stock |
| 500g | $41 | In-stock |
| 1000g | $80 | In-stock |
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| Cat. No. : | HY-Y1055 |
| M.Wt: | 151.13 |
| Formula: | C5H5N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 0.15 mg/mL (ultrasonic;warming);H2O : < 0.1 mg/mL |
Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].
In Vitro:Guanine (1 h) inhibits Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells, with IC50 of 11.5 μM[2].
Guanine (24 h) shows cytotoxicity against African green monkey Vero cells, with CC50 of 136.5 μM[2].
Guanine (10 μM, 16-40 h) partially antagonizes the cytostatic effect of Mycophenolic acid (HY-B0421) on LAN5 cells[3].
In Vivo:Guanine (200–600 nmol, i.t., 5 min before behavioural evaluation) produces dose-dependent antinociceptive effects in the tail-flick, hot-plate, intraplantar (i.pl.) Glutamate, i.pl. Capsaicin (HY-10448) and Acetic acid (HY-Y0319) pain models[4].
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