Adenine
CAS No. : 73-24-5
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|---|---|---|
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| 100g | $26 | In-stock |
| 250g | $54 | In-stock |
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| Cat. No. : | HY-B0152 |
| M.Wt: | 135.13 |
| Formula: | C5H5N5 |
| Purity: | >98 % |
| Solubility: | H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 10 mg/mL |
Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Adenine can be used to induce chronic kidney injury models. Pharmacokinetic data show that in adult male Sprague-Dawley rats, 20-30 minutes after administration (10 mg/kg, i.v.), the Adenine content in blood dialysate samples is 0.78 μg/mL[4].
Administration: 0.2% Adenine in diet; 3 weeks
Rat: Sprague-Dawley (SD) • male • 8 weeks of age
Administration: 0.5% Adenine in diet; 3 weeks
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