L-Tryptophan
CAS No. : 73-22-3
(Synonyms: Tryptophan; Tryptophane)
| Size | Price | Stock |
|---|---|---|
| 25g | $8 | In-stock |
| 100g | $10 | In-stock |
| 500g | $48 | In-stock |
| 1000g | $72 | In-stock |
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| Cat. No. : | HY-N0623 |
| M.Wt: | 204.23 |
| Formula: | C11H12N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 7.69 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels[1][2][3].
In Vitro: L-Tryptophan (Tryptophan; 500, 1000 μM; 48 h) with high levels markedly suppresses pTr2 cell proliferation and increases the percentages of cells in the G1 phase of cell cycle[1].
L-Tryptophan (10 μM; for three weeks) enhances migration, colony formation and osteogenic differentiation of hBMSCs in vitro[2].
L-Tryptophan (10 μM; for three weeks) decreases mRNA levels of adipogenic markers PPARγ and LPL[2].
In Vivo: L-Tryptophan (Tryptophan; 10, 50 kg/mg/day; Intraperitoneally; for consecutive three weeks) enhances migration, colony formation and osteogenic differentiation of mBMSCs in vivo with 50 mg/kg/day[1].
L-Tryptophan (50 mg/kg/day; Intraperitoneally; for consecutive three weeks) accelerates bone regeneration in mouse femur surgical defect[1].
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