Cordycepin
CAS No. : 73-03-0
(Synonyms: 3'-Deoxyadenosine)
| Size | Price | Stock |
|---|---|---|
| 100mg | $19 | In-stock |
| 250mg | $34 | In-stock |
| 1g | $48 | In-stock |
| 5g | $129 | In-stock |
| 10g | $257 | In-stock |
| 25g | $456 | In-stock |
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| Cat. No. : | HY-N0262 |
| M.Wt: | 251.25 |
| Formula: | C10H13N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2]. IC50 & Target:MMP-1, MMP-3[1] In Vitro: Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1].
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