PF-9366
CAS No. : 72882-78-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $115 | In-stock |
| 10mg | $172 | In-stock |
| 25mg | $309 | In-stock |
| 50mg | $432 | In-stock |
| 100mg | $605 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107778 |
| M.Wt: | 350.84 |
| Formula: | C20H19ClN4 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.
IC50 & Target: IC50: 420 nM (Mat2A)[1]
Kd: 170 nM (Mat2A)[1]
In Vitro: PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.
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