SKF-86002
CAS No. : 72873-74-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $160 | In-stock |
| 50mg | $510 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-12511 |
| M.Wt: | 297.35 |
| Formula: | C16H12FN3S |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid[1][2][3].
In Vitro: SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV)[1].
SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells[1].
SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels[4].
In Vivo: SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity[5].
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